Impact of hormone therapy on acute radiotherapy toxicity in the treatment of prostate cancer
Authors:
Open Access
- 28 June 2005
- journal article
- research article
- Published by Springer Nature in Prostate Cancer and Prostatic Diseases
- Vol. 8 (3) , 224-228
Abstract
Purpose: To analyze the impact of neoadjuvant hormone therapy (HT) on acute gastrointestinal (GI) and genitourinary (GU) toxicity from radiotherapy (RT). Scope: The toxicity rates of 480 consecutive prostate cancer patients were reviewed and compared using the χ2 test. Ordered logit regression analyses were performed including the major demographic, disease, and treatment factors. Although no reduction in acute GI toxicity from HT use was observed (P=0.067), a lower rate of acute GU toxicity was observed (P=0.002). No factor reached statistical significance on regression analysis. Conclusions: Observed toxicity rates were similar or lower in patients receiving HT. Thus, increased RT toxicity should not be a concern when deciding to add neoadjuvant HT to RT for prostate cancer.Keywords
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