The proteasome controls ESCRT-III–mediated cell division in an archaeon

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Abstract
Proteasomal control of division in Archaea: In eukaryotes, proteasome-mediated degradation of cell cycle factors triggers mitotic exit, DNA segregation, and cytokinesis, a process that culminates in abscission dependent on the protein ESCRT-III. By studying cell division in an archaeal relative of eukaryotes, Tarrason Risa et al. identified a role for the proteasome in triggering cytokinesis by an archaeal ESCRT-III homolog. Cell division in this archaeon was driven by stepwise remodeling of a composite ESCRT-III–based division ring, where rapid proteasome-mediated degradation of one ESCRT-III subunit triggered the constriction of the remaining ESCRT-III–based copolymer. These data strengthen the case for the eukaryotic cell division machinery having its origins in Archaea. Science , this issue p. eaaz2532
Funding Information
  • Wellcome (203276/Z/16/Z)
  • Francis Crick Institute (FC001999)
  • Medical Research Council (MC_EX_G0800785)
  • Cancer Research UK (C33246/A20147)
  • Human Frontier Science Program (LT001027/2019)
  • Vetenskapsrådet (621-2013-4685)
  • BBSRC (BB/K009001/1)
  • MRC (MC_CF12266)
  • BBSRC Doctoral Training Grant (RG53842)

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