Histone deacetylase 11 inhibits interleukin 10 in B cells of subjects with allergic rhinitis

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Abstract
Background: The interleukin (IL)‐10 expression in B cells plays an important role in immune tolerance. The regulation of IL‐10 expression in B cells is not fully understood yet. Tumor necrosis factor (TNF) is increased in allergic rhinitis (AR) patients. This study tests a hypothesis that TNF enhances histone deacetylase (HDAC)11 expression to inhibit the expression of IL‐10 in B cells of AR patients.Methods: Peripheral B cells were collected from healthy persons and patients with AR. The B cells were analyzed by immune assay and molecular biological approaches for the expression of IL‐10.Results: The expression of HDAC11 was higher in B cells of patients with AR than that in healthy persons. The expression of IL‐10 in B cells was lower in AR patients than that in healthy subjects. The levels of HDAC11 in B cells were negatively correlated with the levels of IL‐10. Exposure of B cells to TNF in the culture inhibited the expression of IL‐10, in which HDAC11 played a critical role in the interference with the Il10 gene transcription. Inhibition of HDAC11 restored the IL‐10 expression in B cells from AR patients and attenuated the experimental AR.Conclusion: TNF can suppress the expression of IL‐10 in B cells via enhancing the expression of HDAC11. Inhibition of HDAC11 restores the IL‐10 expression in B cells of AR subjects. HDAC11 may be a novel target for the treatment of AR.
Funding Information
  • National Natural Science Foundation of China (81503623, 31570932, 81400001, 81571790, 81501573)

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