Synthesis and evaluation of tricyclic derivatives containing a non-aromatic amide as inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)
Authors:
- Kwangwoo ChunKCKwangwoo Chun
- Bo-Young JoeBJBo-Young Joe
- Ji-Seon ParkJPJi-Seon Park
- Young-Chul KimYKYoung-Chul Kim
- Ji-Soo ChoiJCJi-Soo Choi
- Dong-Kyu RyuDRDong-Kyu Ryu
- Seong-Ho KohSKSeong-Ho Koh
- Goang Won ChoGCGoang Won Cho
- Seung Hyun KimSKSeung Hyun Kim
- Myung-Hwa KimMKMyung-Hwa Kim
- 1 April 2010
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 20 (7) , 2250-2253
Abstract
No abstract availableKeywords
This publication has 20 references indexed in Scilit:
- Rational design of conformationally restricted quinazolinone inhibitors of poly(ADP-ribose)polymeraseBioorganic & Medicinal Chemistry Letters, 2007
- PARP Inhibitor Development for Systemic Cancer TargetingAnti-Cancer Agents in Medicinal Chemistry, 2007
- Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modelingBioorganic & Medicinal Chemistry, 2006
- Poly(ADP‐ribose)The FEBS Journal, 2005
- PARP-1 inhibition to treat cancer, ischemia, inflammationPharmacological Research, 2005
- The role of poly(ADP-ribose) in the DNA damage signaling networkBiochemistry and Cell Biology, 2005
- The PARP superfamilyBioEssays, 2004
- Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signalingTrends in Pharmacological Sciences, 2004
- Anticancer Chemosensitization and Radiosensitization by the Novel Poly(ADP-ribose) Polymerase-1 Inhibitor AG14361JNCI: Journal of the National Cancer Institute, 2004
- Design and Synthesis of Poly ADP-ribose Polymerase-1 Inhibitors. 2. Biological Evaluation of Aza-5[H]-phenanthridin-6-ones as Potent, Aqueous-Soluble Compounds for the Treatment of Ischemic InjuriesJournal of Medicinal Chemistry, 2003