Use of single-pill combination therapy in the evolving paradigm of hypertension management

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Abstract
The use of antihypertensive therapy is an evolving paradigm. Although blood pressure (BP) control rates remain low, there have been improvements that may be attributable in part to a recent shift in clinical guidelines that recognizes that most patients will require multiple drugs to reach BP goals and encourages clinicians to use combination therapy as first-line treatment in selected patients. Single-pill combinations of two complementary antihypertensive medications offer benefits beyond those of separate administration of the individual component agents, providing a simpler medication regimen that is effective and well tolerated while enhancing patient adherence to therapy. In the future, there may be single-pill combinations of three antihypertensive drugs to further enhance BP control rates.

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