Supplemental Figure S3 from On-Target Effect of FK866, a Nicotinamide Phosphoribosyl Transferase Inhibitor, by Apoptosis-Mediated Death in Chronic Lymphocytic Leukemia Cells

Authors:
  • IGIris Gehrke
    Iris Gehrke
  • EBEric D.J. Bouchard
    Eric D.J. Bouchard
  • SBSara Beiggi
    Sara Beiggi
  • APArmando G. Poeppl
    Armando G. Poeppl
  • JJJames B. Johnston
    James B. Johnston
  • SGSpencer B. Gibson
    Spencer B. Gibson
  • VBVersha Banerji
    Versha Banerji
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Abstract
Figure S3: Cells were treated for one, two or three days with FK866 at 1 nM, 10 nM and 50 nM. A) AMPK was phosphorylated at all concentrations at day 1, but only at 1 nM after three days incubation with FK866. B) mTOR was phosphorylated at 1 nM and 10 nM FK866 at day 2. C) Erk1/2 was phosphorylated at 1 nM FK866 at day 2. Vinculin served as loading control. Ctrl: vehicle control