A Family of AMPA-Selective Glutamate Receptors
Authors:
- 3 August 1990
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 249 (4968) , 556-560
Abstract
Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ hybridization revealed differential expression patterns of the cognate mRNAs throughout the brain. Functional expression of the cDNAs in cultured mammalian cells generated receptors displaying α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective binding pharmacology (AMPA = quisqualate > glutamate > kainate) as well as cation channels gated by glutamate, AMPA, and kainate and blocked by 6,7-dinitroquinoxaline-2,3-dione (CNQX).Keywords
This publication has 42 references indexed in Scilit:
- Regulation of synaptic transmission in the central nervous system: Long-term potentiationCell, 1989
- Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTPScience, 1989
- An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiationNature, 1989
- A specific quisqualate agonist inhibits kainate responses induced in Xenopus oocytes injected with rat brain RNANeuroscience Letters, 1989
- The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous SystemAnnual Review of Pharmacology and Toxicology, 1989
- Glutamate neurotoxicity and diseases of the nervous systemNeuron, 1988
- An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2Nature, 1987
- Quantitative in situ hybridization histochemistry reveals increased levels of corticotropin-releasing factor mRNA after adrenalectomy in ratsNeuroscience Letters, 1986
- Distribution of [3H]AMPA binding sites in rat brain as determined by quantitative autoradiographyBrain Research, 1984
- Structural homology of Torpedo californica acetylcholine receptor subunitsNature, 1983