Highly Enantioselective Nickel‐Catalyzed Intramolecular Reductive Cyclization of Alkynones
Authors:
- 16 January 2015
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 54 (8) , 2520-2524
Abstract
The first asymmetric nickel‐catalyzed intramolecular reductive cyclization of alkynones is reported. A P‐chiral monophosphine and triethylsilane were used as the ligand and the reducing reagent, respectively, to form a series of tertiary allylic alcohols bearing furan/pyran rings in excellent yields and enantioselectivities. This reaction has a broad substrate scope and enabled the efficient synthesis of dehydroxycubebin and chiral dibenzocyclooctadiene skeletons.Keywords
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