Analgesic activity of the new A1/A2a agonist, the Cl–Ala-OH-AR compound
Authors:
- Mariya S. PshenichnikovaMPMariya S. Pshenichnikova
- Dmitry S. YakovlevDYDmitry S. Yakovlev
- Alexander A. SpasovAlexander A. Spasov
- Raul I. MusaevRMRaul I. Musaev
- Kristina I. AdzhienkoKAKristina I. Adzhienko
- Maria L. UsachevaMUMaria L. Usacheva
- Elena V. DorofeevaEDElena V. Dorofeeva
- Maria Ya. BerzinaMaria Ya. Berzina
- Irina D. KonstantinovaIKIrina D. Konstantinova
Open Access
- 5 October 2025
- journal article
- Published by Volgograd State Medical University in Volgograd Journal of Medical Research
- Vol. 22 (3) , 12-18
Abstract
In this study, the analgesic activity of the Cl-Ala-OH-AR compound was evaluated in various models of somatogenic somatic pain. The results showed that the Cl-Ala-OH-AR compound significantly increases the latency of the reaction in tests of the formation of thermal somatic pain, such as "Hot plate" and "Tail Twitching", however, its effectiveness was lower than that of tramadol and adenosine. In the algogen-induced somatic pain model evaluated in the formalin test, Cl-Ala-OH-AR demonstrated more pronounced analgesic properties, especially in the inflammatory phase, where the reduction in pain reactions was 3.4 times greater than the effect of adenosine. These results indicate a significant analgesic potential of Cl-Ala-OH-AR in the context of somatogenic somatic pain caused by algogens, which opens up prospects for further study.Keywords
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