Ubiquitin C‑terminal hydrolase‑L1: A new cancer marker and therapeutic target with dual effects (Review)

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Abstract
Ubiquitin C‑terminal hydrolase‑L1 (UCH‑L1), a member of the lesser‑known deubiquitinating enzyme family, has deubiquitinase and ubiquitin (Ub) ligase activity and the role of stabilizing Ub. UCH‑L1 was first discovered in the brain and is associated with regulating cell differentiation, proliferation, transcriptional regulation and numerous other biological processes. UCH‑L1 is predominantly expressed in the brain and serves a role in tumor promotion or inhibition. There is still controversy about the effect of UCH‑L1 dysregulation in cancer and its mechanisms are unknown. Extensive research to investigate the mechanism of UCH‑L1 in different types of cancer is key for the future treatment of UCH‑L1‑associated cancer. The present review details the molecular structure and function of UCH‑L1. The role of UCH‑L1 in different types of cancer is also summarized and how novel treatment targets provide a theoretical foundation in cancer research is discussed.

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