Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA G‐Quadruplexes
Open Access
- 15 September 2022
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 2022 (35)
Abstract
The synthesis and characterization of a small series of cyclic triimidazole derivatives functionalized with methylated pyridine or guanidine moieties is reported. These compounds were tested for their ability to bind to G‐quadruplexes from both telomeric and oncogene promoter sequences. Some of them exhibited high affinity and effective G‐quadruplex‐stabilizing properties. Overall, these compounds may represent useful leads for developing more potent and selective analogues.Keywords
This publication has 42 references indexed in Scilit:
- Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?Nature Reviews Drug Discovery, 2011
- Facile Synthesis and Structures of Cyclic Triimidazole and Its Boric Acid AdductCrystal Growth & Design, 2011
- Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motifChemical Communications, 2010
- A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad DynamicsJournal of the American Chemical Society, 2009
- Polymorphism of human telomeric quadruplex structuresBiochimie, 2008
- A hitchhiker's guide to G-quadruplex ligandsOrganic & Biomolecular Chemistry, 2007
- Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K + solution †Nucleic Acids Research, 2007
- Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequenceNucleic Acids Research, 2007
- NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter regionNucleic Acids Research, 2006
- Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solutionNucleic Acids Research, 2006