Ball milling for the quantitative and specific solvent-free Knoevenagel condensation + Michael addition cascade in the synthesis of various 2-amino-4-aryl-3-cyano-4H-chromenes without heating
Open Access
- 11 September 2014
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in RSC Advances
- Vol. 4 (89) , 48191-48201
Abstract
Various 2-amino-4-aryl-3-cyano-4H-chromenes have been quantitatively prepared by dry ball milling in the presence of catalytic Na2CO3. The orientation specificities are discussed; existing misattributions are pointed out and clarified by NMR.Keywords
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