Preparation of Chitosan Based Scaffolds Using Supercritical Carbon Dioxide

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Abstract
A novel chitosan‐formaldehyde porous derivative (scaffolds) was prepared by reaction of 85% deacetylated chitosan with 37% aq. formaldehyde using supercritical carbon dioxide (sc. CO2). Prior to reaction, the chitosan hydrogel was prepared in 1% aq. acetic acid (AcOH) and formaldehyde. The prepared hydrogel was subjected to solvent exchange. The identity of the Schiff base was confirmed by Fourier transform infrared spectroscopy (FTIR). The chitosan‐derivative was evaluated by thermal analysis, scanning electron microscopy, and porosimetry analysis. Overall, the sc. CO2 assisted chitosan derivative opens new perspectives as biomedical material.

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