In Vivo Effects of Follicle-stimulating Hormone on Testicular Macrophages

Authors:
  • JYJ. B. Yee
    J. B. Yee
  • JHJ. C. Hutson
    J. C. Hutson
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Abstract
The effect of an intraperitoneal injection of various hormones on the incorporation of amino acids and uridine into acid-precipitable material by subsequently isolated testicular macrophages was investigated. It was found that treatment with follicle-stimulating hormone (FSH), but not luteinizing hormone (LH) or insulin, significantly increased incorporation of amino acids into secreted (but not cellular) protein and uridine incorporation into cellular RNA in a dose-dependent manner. Maximal responsiveness was observed at a dose of 50 micrograms of the hormone. These studies demonstrate that FSH has an action on testicular macrophages in vivo.