Pre-emptive opioid sedation during therapeutic hypothermia

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Abstract
Although none of the major cooling trials mandated routine pre-emptive sedation, anecdotal evidence suggests that opioids are widely used during neonatal cooling therapy. We examined the current practice of pre-emptive opioid sedation during cooling therapy in the UK neonatal units and to compare this with major USA and Canadian neonatal units. We designed an electronic survey (Qualtrics LLC, Provo, Utah, USA) with 10 questions covering sedation practices during cooling including the drugs used, dose, duration and the reason for sedation for ventilated and non-ventilated babies. The survey was emailed to the lead clinicians of all 52 UK cooling centres directly. In the USA/Canada, the survey was distributed through the Neurocritical Care Special Interest Group, which is a virtual worldwide network of brain researchers. Responses were then screened for duplications and data completeness prior to analysis. All 52 (100% response rate) UK and 34 of the USA/Canadian cooling centres completed …
Funding Information
  • National Institute for Health Research
  • Medical Research Council

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