Airway microbiome in adult survivors of extremely preterm birth: the EPICure study
- 21 November 2018
- journal article
- research article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 53 (1) , 1801225
Abstract
Bronchopulmonary dysplasia (BPD) is a major complication of preterm birth that leads to lifelong respiratory morbidity. The EPICure study has investigated the longitudinal health outcomes of infants born extremely preterm (EP; Prevotella melaninogenicawas significantly lower in the preterm group compared to controls. This decline was balanced by a nonsignificant increase in Firmicutes.TotalPrevotellarelative abundance correlated with forced expiratory volume in 1 s z-score (ρ=0.272; p,extremely preterm birth is associated with a significant dysbiosis in airway microbiome in young adulthood regardless of neonatal BPD status. This is characterised by a shift in the community composition away from Bacteriodetes as manifested in a significant drop inPrevotellarelative abundance.Keywords
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