Agriculture has long relied on chemical inputs such as pesticides, herbicides, and synthetic fertilizers to maintain crop productivity, often leading to environmental degradation and health concerns. This review aims to evaluate the potential of transgenic crops to reduce dependence on such inputs while supporting sustainable agriculture. Transgenic plants, developed through genetic engineering, incorporate desirable traits such as insect resistance, herbicide tolerance, and disease resistance, enabling crops to better withstand biotic stresses. Evidence from multiple studies indicates that insect-resistant crops, particularly Bt cotton and Bt maize, have contributed to notable reductions in insecticide use and improved crop yields in several regions. In some cases, these crops have also enhanced ecological balance by supporting beneficial organisms. However, the widespread adoption of herbicide-tolerant crops has raised concerns regarding increased herbicide application and the emergence of resistant weed species. This review synthesizes findings from existing literature to examine the extent to which transgenic crops reduce chemical inputs, their environmental and socio-economic impacts, and their role in modern agricultural systems. It also highlights key challenges, including resistance development, regulatory issues, and public acceptance. Overall, transgenic crops present a promising approach to minimizing chemical dependency, but their long-term sustainability depends on responsible management practices and integrated agricultural strategies.