Amino alcohol effects on the ruthenium(II)-catalysed asymmetric transfer hydrogenation of ketones in propan-2-ol

Authors:
  • JTJun Takehara
    Jun Takehara
  • SHShohei Hashiguchi
    Shohei Hashiguchi
  • AFAkio Fujii
    Akio Fujii
  • SIShin-Ichi Inoue
    Shin-Ichi Inoue
  • TITakao Ikariya
    Takao Ikariya
  • RNRyoji Noyori
    Ryoji Noyori
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Abstract
A ruthenium(II) complex generated in situ from [{RuCl2(η6-C6Me6)}2], (1S,2S)-2-methylamino-1,2-diphenylethanol and KOH serves as an efficient catalyst for asymmetric transfer hydrogenation of acetophenone derivatives in propan-2-ol to give (S)-enriched alcohols in up to 92% ee and in > 90% yield.