Retinoids stimulate the release of superoxide by neutrophils and change their morphology
Authors:
- 1 May 1986
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 127 (2) , 223-228
Abstract
All‐trans‐retinal stimulated the release of superoxide by human and guinea pig neutrophils 63 ± 14 SD and 53 ± 5 SD nmol of O2−/min/107 cells, respectively. Superoxide release by unstimulated cells was negligible. All‐trans‐retinal also induced morphological changes (i.e., evaginations) in these cells. Other retinoids were effective in instigating these phenomena. The similarities of these effects to those instigated by cis‐unsaturated fatty acids (Badwey, J.A., et al., 1984, J. Biol. Chem., 259:7870–7877) are discussed in light of possible mechanisms.Keywords
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