Epidemiologic Study of the Predisposing Factors in Erythema toxicum neonatorum

Authors:
  • JFJie Feng
    Jie Feng
  • RQRui Qu
    Rui Qu
  • HZHui Zhou
    Hui Zhou
  • HMHuiqun Ma
    Huiqun Ma
  • XNXinwu Niu
    Xinwu Niu
  • QDQianli Dang
    Qianli Dang
  • XZXianqi Zhang
    Xianqi Zhang
  • ZTZhongwei Tian
    Zhongwei Tian
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Abstract
Background: Erythema toxicum neonatorum (ETN) is a very common disease, but its predisposing factors are still unknown. Objective: To determine the predisposing factors of ETN. Methods: Seven hundred and eighty-three neonates born in the same hospital during the same period were investigated, and the factors predisposing to ETN were evaluated in a case-control study. Results: (1) The incidence of ETN is about 43.68%, and it is significantly higher in males than in females (p < 0.001). (2) Term birth (p < 0.05), first-pregnancy birth (p < 0.001), the birth season (summer and autumn, p < 0.005), being fed with milk powder substitute or a mixed diet (p < 0.001) and vaginal delivery (p < 0.001) are the predisposing factors of ETN. (3) The severity of ETN in neonates born by vaginal delivery is significantly correlated with the total length of labor (p < 0.001). Conclusion: Our findings suggest that environmental factors play an important role in the onset of ETN.