Toward faster and higher resolution LA–ICPMS imaging: on the co-evolution of LA cell design and ICPMS instrumentation
- 11 January 2016
- journal article
- review article
- Published by Springer Nature in Analytical and Bioanalytical Chemistry
- Vol. 408 (11) , 2687-2695
Abstract
We describe trends in fast, high resolution elemental imaging by laser ablation–inductively coupled plasma mass spectrometry (LA–ICPMS). Recently developed low dispersion LA cells deliver quantitative transport of ablated aerosols within 10 ms and also provide enhanced sensitivity compared to conventional LA cells because the analyte ion signal becomes less diluted during aerosol transport. When connected to simultaneous ICPMS instruments, these low dispersion LA cells offer a platform for high speed and high lateral resolution shot-resolved LA–ICPMS imaging. Here, we examine the current paradigms of LA–ICPMS imaging and discuss how newly developed LA cell technology combined with simultaneous ICPMS instrumentation is poised to overcome current instrumental limitations to deliver faster, higher resolution elemental imaging. On means for obtaining high-speed, high-resolution, multielemental images is to combine new lowdispersion laser-ablation cell technology with an inductively coupled plasma time-of-flight mass spectrometer (ICP-TOFMS). Here, we show three selected-isotope LA-ICP-TOFMS images of a hetereogeneous Opalinus clay sampleKeywords
Funding Information
- Seventh Framework Programme (624280)
This publication has 45 references indexed in Scilit:
- High-Speed, High-Resolution, Multielemental LA-ICP-TOFMS Imaging: Part II. Critical Evaluation of Quantitative Three-Dimensional Imaging of Major, Minor, and Trace Elements in Geological SamplesAnalytical Chemistry, 2015
- High-Speed, High-Resolution, Multielemental Laser Ablation-Inductively Coupled Plasma-Time-of-Flight Mass Spectrometry Imaging: Part I. Instrumentation and Two-Dimensional Imaging of Geological SamplesAnalytical Chemistry, 2015
- Submicrometer Imaging by Laser Ablation-Inductively Coupled Plasma Mass Spectrometry via Signal and Image Deconvolution ApproachesAnalytical Chemistry, 2015
- Development of a fast laser ablation-inductively coupled plasma-mass spectrometry cell for sub-μm scanning of layered materialsJournal of Analytical Atomic Spectrometry, 2014
- Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometryNature Methods, 2014
- Fast Chemical Imaging at High Spatial Resolution by Laser Ablation Inductively Coupled Plasma Mass SpectrometryAnalytical Chemistry, 2013
- Imaging of metals in biological tissue by laser ablation inductively coupled plasma mass spectrometry (LA–ICP–MS): state of the art and future developmentsJournal of Mass Spectrometry, 2013
- Solid sample analysis using laser ablation inductively coupled plasma mass spectrometryTrAC Trends in Analytical Chemistry, 2005
- Two-Dimensional Mapping of Copper and Zinc in Liver Sections by Laser Ablation–Inductively Coupled Plasma Mass SpectrometryClinical Chemistry, 2003
- Solid sample introduction by laser ablation for inductively coupled plasma source mass spectrometryThe Analyst, 1985