Antidepressants Inhibit Enkephalin Binding to Synaptosome-Enriched Fractions of Rat Brain
Authors:
- Eugene SomozaESEugene Somoza
- Alicia GalindoAGAlicia Galindo
- Eulalia BazánEBEulalia Bazán
- Antonio GuillamónAGAntonio Guillamón
- Azucena ValenciaAVAzucena Valencia
- Jose-Angel FuentesJFJose-Angel Fuentes
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Neuropsychobiology
- Vol. 7 (6) , 297-301
Abstract
Several tricyclic and nontricyclic antidepressants have been found to inhibit the binding of tritiated met-enkephalin to synaptosome-enriched fractions prepared from whole brain of rat in Tris-HCl media. The values of the ID50 are in the range of 9–44 µM.Keywords
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