Local and Regional Therapies for Hepatocellular Carcinoma

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Abstract
Local and regional therapies are recommended for patients with hepatocellular carcinoma (HCC) in very early (BCLC 0), early (BCLC A), and intermediate stages (BCLC B. However, in clinical practice the decision to select one of the available approaches has to take into account several parameters that go far beyond the general recommendations exposed in clinical practice guidelines. Adequate selection of candidates for each option with proven survival benefit is key to secure an optimal outcome in terms of survival, while avoiding major morbidity and securing the best quality of life. This assessment to recommend treatment requires the effective collaboration of a multidisciplinary tumor board so that a personalized approach is in place. This review provides a comprehensive up‐to‐date overview of available techniques, explaining the advantages and disadvantages of the different loco‐regional treatments. It aims to provide guidance for evidence based treatment decisions, while also pointing out the current limitations and future prospects that need to be confirmed by ongoing research.

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