Antibacterial activity of AM-1155 against penicillin-resistant Streptococcus pneumoniae
Authors:
Open Access
- 1 January 1998
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 41 (1) , 103-106
Abstract
AM-1155, a novel fluoroquinolone, exhibited potent activity against Streptococcus pneumoniae, including penicillin-resistant strains; the MIC90 for 48 clinical isolates was 0.25 mg/L. The antibacterial activity of AM-1155 against S. pneumoniae was higher than that of levofloxacin (MIC90 1 mg/L) and comparable with that of sparfloxacin. The MIC90s of penicillin G and erythromycin were 2 and > 4 mg/L, respectively. AM-1155 showed no cross-resistance to penicillin or erythromycin. For experimental murine pneumonia with S. pneumoniae intermediately resistant to penicillin, oral administration of AM-1155 showed efficacy higher than that of levofloxacin and equal to that of sparfloxacin. The efficacy of AM-1155 was also equal to that of subcutaneous penicillin G administration at the same dosage.Keywords
This publication has 8 references indexed in Scilit:
- Noncompromised penicillin-resistant pneumococcal pneumonia CBA/J mouse model and comparative efficacies of antibiotics in this modelAntimicrobial Agents and Chemotherapy, 1996
- Incidence of penicillin-resistant streptococcus pneumoniae in Japan, 1993–1995Journal of Infection and Chemotherapy, 1996
- Therapeutic Efficacies of Penicillin G, Cefotaxime, and Imipenem/Cilastatin against Penicillin-Resistant Pneumococcal Pneumonia in CBA/J MiceJournal of Infection and Chemotherapy, 1996
- In vitro antibacterial activity of AM-1155, a novel 6-fluoro-8-methoxy quinoloneAntimicrobial Agents and Chemotherapy, 1994
- In vivo efficacy of a new fluoroquinolone, sparfloxacin, against penicillin-susceptible and -resistant and multiresistant strains of Streptococcus pneumoniae in a mouse model of pneumoniaAntimicrobial Agents and Chemotherapy, 1992
- Antimicrobial Resistance in Streptococcus pneumoniae: An OverviewClinical Infectious Diseases, 1992
- Susceptibilities of penicillin-susceptible and -resistant strains of Streptococcus pneumoniae to RP 59500, vancomycin, erythromycin, PD 131628, sparfloxacin, temafloxacin, win 57273, ofloxacin, and ciprofloxacinAntimicrobial Agents and Chemotherapy, 1992
- A review of antibiotic resistance patterns of Streptococcus pneumoniae in EuropeJournal of Antimicrobial Chemotherapy, 1991