Cytochrome P450 drug interactions with statin therapy

Authors:

XGXw Goh
Xw Goh
CHCh How
Ch How
STS Tavintharan
S Tavintharan

1 March 2013

journal article
Published by Medknow in Singapore Medical Journal

Vol. 54 (3) , 131-135
DOI:10.11622/smedj.2013044
PMID:23546024

Abstract

Statins are commonly used in the treatment of hyperlipidaemia. Although the benefits of statins are well-documented, they have the potential to cause myopathy and rhabdomyolysis due to the complex interactions of drugs, comorbidities and genetics. The cytochrome P450 family consists of major enzymes involved in drug metabolism and bioactivation. This article aims to highlight drug interactions involving statins, as well as provide updated recommendations and approaches regarding the safe and appropriate use of statins in the primary care setting.

Keywords

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