Remote Site‐Selective Asymmetric Protoboration of Unactivated Alkenes Enabled by Bimetallic Relay Catalysis
Authors:
- 8 April 2022
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 61 (23) , e202202713
Abstract
A remote C(sp3)−H bond asymmetric borylation of unactivated alkenes was achieved by bimetallic relay catalysis. The reaction proceeded through reversible and consecutive β‐H elimination/olefin insertion promoted by CoH species generated in situ, followed by copper‐catalyzed asymmetric protoboration. The use of this synergistic Co/Cu catalysis protocol allowed the enantioselective protoboration of various unactivated terminal alkenes and internal alkenes, as well as an unrefined mixture of olefin isomers, at the distal less‐reactive β‐position to a functional group, leading to chiral organoboronates.Keywords
Funding Information
- National Natural Science Foundation of China (22171042, 21831002, 22193012)
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