Effect of estrogens on apomorphine-induced circling behavior in the rat

Authors:
  • PBP. Bédard
    P. Bédard
  • JDJ. Dankova
    J. Dankova
  • RBR. Boucher
    R. Boucher
  • PLP. Langelier
    P. Langelier
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Abstract
The effect of administration of estrogens parenterally for 1 week was tested on apomorphine-induced circling in a group of castrated female rats with a lesion of the left entopeduncular nucleus. We observed a significant decrease in the number of turns per minute in estrogen-treated animals as compared with controls. Our tentative explanation is that estrogens decrease the sensitivity of dopamine receptors in the striatum.