Influence of antiTNF-alpha antibody treatment on fracture healing under chronic inflammation
Open Access
- 29 May 2014
- journal article
- research article
- Published by Springer Nature in BMC Musculoskeletal Disorders
- Vol. 15 (1) , 184
Abstract
The overexpression of tumor necrosis factor (TNF)-α leads to systemic as well as local loss of bone and cartilage and is also an important regulator during fracture healing. In this study, we investigate how TNF-α inhibition using a targeted monoclonal antibody affects fracture healing in a TNF-α driven animal model of human rheumatoid arthritis (RA) and elucidate the question whether enduring the anti TNF-α therapy after trauma is beneficial or not.Keywords
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