Histone Modifications and their Role in Epigenetics of Cancer
- 1 April 2022
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Current Medicinal Chemistry
- Vol. 29 (14) , 2399-2411
Abstract
: Epigenetic regulations play a crucial role in the expression of various genes that are important in the normal cell function. Any alteration in these epigenetic mechanisms can lead to the modification of histone and DNA, resulting in the silencing or enhanced expression of some genes causing various diseases. Acetylation, methylation, ribosylation, or phosphorylation of histone proteins modifies its interaction with the DNA, consequently changing the ratio of heterochromatin and euchromatin. Terminal lysine residues of histone proteins serve as potential targets of such epigenetic modifications. The current review focuses on the histone modifications, and their contributing factors; the role of these modifications on metabolism leads to cancer, and methylation of histone in cancer affects the DNA repair mechanisms.Keywords
This publication has 80 references indexed in Scilit:
- Histone Demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Protein Nuclear StabilizationPLOS ONE, 2012
- Molecular and Epigenetic Mechanisms of MLL in Human LeukemogenesisCancers, 2012
- Type II Arginine Methyltransferase PRMT5 Regulates Gene Expression of Inhibitors of Differentiation/DNA Binding Id2 and Id4 during Glial Cell DifferentiationJournal of Biological Chemistry, 2011
- Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone ModificationCell, 2011
- Regulation of chromatin by histone modificationsCell Research, 2011
- Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effectInvestigational New Drugs, 2010
- Global Histone H4 Acetylation and HDAC2 Expression in Colon Adenoma and CarcinomaDigestive Diseases and Sciences, 2008
- N-formylation of lysine in histone proteins as a secondary modification arising from oxidative DNA damageProceedings of the National Academy of Sciences, 2007
- A genomic code for nucleosome positioningNature, 2006
- Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancerNature Genetics, 2005