Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy
Open Access
- 27 May 2024
- journal article
- review article
- Published by MDPI AG in Pharmaceuticals
- Vol. 17 (6) , 692
Abstract
There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in a broad range of characteristics and biological effects. Polyphenols can be found in a variety of foods and drinks, including fruits, cereals, tea, and coffee. Studies both in vitro and in vivo, as well as clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, and health advantages. Dietary polyphenols have demonstrated the potential to prevent many health problems, including obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, and neurological diseases. In this paper, the protective effects of polyphenols and the mechanisms behind them are investigated in detail, citing the most recent available literature. This review aims to provide a comprehensive overview of the current knowledge on the role of polyphenols in preventing and managing chronic diseases. The cited publications are derived from in vitro, in vivo, and human-based studies and clinical trials. A more complete understanding of these naturally occurring metabolites will pave the way for the development of novel polyphenol-rich diet and drug development programs. This, in turn, provides further evidence of their health benefits.Keywords
Funding Information
- The Deanship of Scientific Research, Vice Presidency (GrantA461)
This publication has 303 references indexed in Scilit:
- Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's DiseaseMolecular Nutrition & Food Research, 2022
- Biochanin‐A has antidiabetic, antihyperlipidemic, antioxidant, and protective effects on diabetic nephropathy via suppression of TGF‐β1 and PAR‐2 genes expression in kidney tissues of STZ‐induced diabetic ratsBiotechnology and Applied Biochemistry, 2021
- Curcumin Reduces Adipose Tissue Inflammation and Alters Gut Microbiota in Diet‐Induced Obese Male MiceMolecular Nutrition & Food Research, 2021
- Resveratrol chemosensitizes adriamycin‐resistant breast cancer cells by modulating miR‐122‐5pJournal of Cellular Biochemistry, 2019
- Potentiation of paclitaxel effect by resveratrol in human breast cancer cells by counteracting the 17β‐estradiol/estrogen receptor α/neuroglobin pathwayJournal of Cellular Physiology, 2018
- p‐Coumaric acid, a dietary polyphenol ameliorates inflammation and curtails cartilage and bone erosion in the rheumatoid arthritis rat modelBioFactors, 2017
- Trans‐resveratrol simultaneously increases cytoplasmic Ca2+ levels and nitric oxide release in human endothelial cellsMolecular Nutrition & Food Research, 2011
- The actions of fisetin on glucose metabolism in the rat liverCell Biochemistry and Function, 2010
- Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell linesMolecular Nutrition & Food Research, 2006
- Olive Oil and Reduced Need for Antihypertensive MedicationsArchives of internal medicine (1960), 2000