Chemically Bonded Stationary Phases--Preparation and Application to High Speed Liquid Chromatography

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Abstract
The aim of this review is to discuss the preparation of chemically bonded stationary phases, and the impact which these have already had in high speed liquid chromatography (HSLC). Methods by which the surface of silica may be modified with a variety of organic coatings are discussed. Also mentioned are the stabilities and retention mechanism of the modified supports and, where possible, comparisons are made with conventional supports. Finally applications of the materials to a wide range of problems are discussed.