Synthesis and Hypolipidemic Activity of Diesters of Arylnaphthalene Lignan and Their Heteroaromatic Analogs.

Authors:
  • KKKazuhiko Kondo
    Kazuhiko Kondo
  • TITameo Iwasaki
    Tameo Iwasaki
  • AOAkio Ohtani
    Akio Ohtani
  • KTKohki Takashima
    Kohki Takashima
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Abstract
A series of diesters of arylnaphthalene lignan and their heteroaromatic analogs were synthesized and evaluated for hypolipidemic activity. The disasters with modifications at C-3 showed excellent hypocholesterolemic and high-density lipoprotein (HDL) cholesterol-elevating activities. Structure-activity analysis indicated that the 2-pyridylmethyl ester 5l has the optimum activity.