PHARMACOKINETICS OF GALANTHAMINE (A LONG-ACTING ANTICHOLINESTERASE DRUG) IN ANAESTHETIZED PATIENTS

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Abstract
The pharmacokinetics of the long-acting anti-cholinesterase drug, galanthamine, were investi-gated in eight patients. After i.v. injection of 0.3 mg kg−1, the decrease in the serum concen-tration of galanthamine followed a biexponential curve. The serum concentration decreased rapidly from 543±47 ng ml−1 to 128±14 ng ml−1 be-tween 2 and 30 min with a T½α of 6.42 ± 2.15 min, and then declined more slowly with a T½β of 264±28min. Total serum clearance of galanthamine amounted to 5.37±0.87ml min−1 kg−1, and the renal clearance was 1.36±0.10 ml min−1 kg−1. The cumulative urinary excretion of galanthamine between 0 and 48 h after injection amounted to 28.0±5.4% of the administered dose. The biliary excretion of galanthamine during 24 h amounted to 0.2 ±0.1% of the dose. There was no evidence of glucuronide or sulphate conjugation of galanthampine.

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