Introduction: Work related musculoskeletal disorders (WRMSDs) are currently one of the leading causes of disability worldwide. However, information on their prevalence and associated factors remains insufficient in Cameroon. Objective: Determine the prevalence and associated factors of WRMSDs among the staff of the University of Dschang (UDs). Methods: We conducted a descriptive cross-sectional study from 05 February to 18 March 2020 during which a modified Nordic Musculoskeletal Questionnaire (NMQ) was administered face-to-face with participants. A convenient type non-probability sampling was used for the selection of participants. The data collected were analyzed with EPI info 7.2.2.6. A bi-variate analysis was conducted to determine factors associated with WRMSDs. Results: We enrolled 425 participants. The 12-month prevalence of WRMSDs was 93.88%. Almost half of the participants (49.18%) were prevented from their normal activities due to WRMSDs in the past 12 months. The most affected body region was the lower back with a prevalence of 71. 53%. The occurrence of WRMSDs at the UDs was significantly associated with: stress (PConclusion: UDs staff is a high-risk population for WRMSDs. It is imperative to protect this human capital by preventing and treating WRMSDs.