Fabrication of Fe3O4/PLLA composites for use in bone tissue engineering

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Abstract
The aim of this study was to incorporate nanoscale Fe3O4 particles into a poly‐l‐lactide (PLLA) matrix to fabricate a magnetic and biodegradable composite. The physical and osteogenic functions of this material were tested. Injection molding was used to fabricate four nano‐Fe3O4/PLLA composites with Fe3O4 mix ratios of 0%, 20%, 30%, and 40% (w/w). X‐ray diffraction and hysteresis loop tests were performed to evaluate the physical properties of the nano‐Fe3O4/PLLA composites. Tensile strength tests showed that the progressive addition of nano‐Fe3O4 particles to the PLLA matrix results in higher elastic modulus and lower tensile strength. Images from scanning electron microscopy demonstrated that osteoblasts cultured on the 20% nano‐Fe3O4/PLLA surface exhibited abundant filaments, which are a morphologic characteristic of osteoblastic differentiation. These results suggest that the 20% nano‐Fe3O4/PLLA composite used in this study has the potential for future tissue engineering applications. POLYM. COMPOS., 38:2881–2888, 2017. © 2016 Society of Plastics Engineers
Funding Information
  • Taipei Medical University
  • National Taipei University of Technology (NTUT-TMU-103-05)

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