Hemiplegic Migraine Associated With PRRT2 Variations
Authors:
- Florence RiantFRFlorence Riant
- Caroline RoosCRCaroline Roos
- Agathe RoubertieARAgathe Roubertie
- Cécile BarbanceCBCécile Barbance
- Jessica HadjadjJHJessica Hadjadj
- Stéphane AuvinSAStéphane Auvin
- Guillaume BailleGBGuillaume Baille
- Marion BeltramoneMBMarion Beltramone
- Cécile BoulangerCBCécile Boulanger
- Alice CahnACAlice Cahn
- Florina CataFCFlorina Cata
- Emmanuel CheuretECEmmanuel Cheuret
- 4 January 2022
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 98 (1) , E51-E61
Abstract
Background and objective: PRRT2 variants have been reported in a few cases of patients with hemiplegic migraine. To clarify the role of PRRT2 in familial hemiplegic migraine, we studied this gene in a large cohort of affected probands. Methods: PRRT2 was analyzed in 860 probands with hemiplegic migraine and PRRT2 mutations were identified in 30 probands. Genotyping of relatives identified a total of 49 persons with mutations whose clinical manifestations were detailed. Results: PRRT2 mutations were found in 12 of 163 probands previously tested negative for CACNA1A, ATP1A2 and SCN1A mutations, and in 18 of 697 consecutive probands screened simultaneously on the four genes. In this second group, pathogenic variants were found in 105 subjects, mostly in ATP1A2 (42%), followed by CACNA1A (26%), PRRT2 (17%) and SCN1A (15%). The PRRT2 mutations included seven distinct variants, five of which already described in persons with paroxysmal kinesigenic dyskinesia, and two new variants. Eight probands had a deletion of the whole PRRT2 gene. Among the 49 PRRT2 mutated patients, 26 had pure hemiplegic migraine, 16 had hemiplegic migraine associated with another manifestation: epilepsy (8), learning disabilities (5), hypersomnia (4) or abnormal movement (3). Three patients had epilepsy without migraine, two had paroxysmal kinesigenic dyskinesia without migraine, and one was asymptomatic. Conclusion: PRRT2 should be regarded as the fourth autosomal dominant gene for hemiplegic migraine, and screened in any affected patient, together with the three other main genes. Further studies are needed to understand how the same loss of function PRRT2 mutations can lead to a wide range of neurologic phenotypes including paroxysmal movement disorder, epilepsy, learning disabilities, sleep disorder and hemiplegic migraine.Keywords
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