STUDIES ON NATURAL IMMUNITY TO PNEUMOCOCCUS TYPE III

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Abstract
The C carbohydrate used in the experiments was prepared by the procedure of Tillett, Goebel and Avery from an R variant of type I pneumococcus. Soluble specific substance was prepared by the procedure of Heidelberger, Goebel and Avery from a type III strain. The previous addition of the C carbohydrate decreased the phagocytosis of rabbit virulent and aviru-lent strains of pneumococcus type III by the cells and serum of both man and the normal rabbit. The addition of anti-R pneumococcus serum to normal rabbit serum and cells resulted in increased phagocytosis of these strains, which effect could be removed by the C carbohydrate. If 100 or more M.L.D. of the virulent strain of type III were injected by the intravenous route, mice could be protected by anti-R pneumococcus rabbit serum. The protective property was found to be absorbed from the serum with C carbohydrate.

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