NEPHROTOXICITY OF PARENTERALLY ADMINISTERED CYCLOSPORINE AFTER ORTHOTOPIC LIVER TRANSPLANTATION

Authors:
  • PPPaul R. Powell-Jackson
    Paul R. Powell-Jackson
  • BYBarbara Young
    Barbara Young
  • RCRoy Y. Calne
    Roy Y. Calne
  • RWRoger Williams
    Roger Williams
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Abstract
The frequency of nephrotoxicity in the absence of identifiable prerenal or postrenal causes within five days of operation in 27 liver transplant recipients was found to be 71% in those treated with i.v. cyclosporine alone, 37.5% with i.m. cyclosporine alone, and 16.7% with prednisolone and azathioprine. Renal failure following i.v. cyclosporine was characterized by an immediate fall in urine output and creatinine clearance with well-preserved tubular function—findings consistent with a reduction in renal blood flow or glomerular filtration rate, or both.