Syntaxin-3 regulates newcomer insulin granule exocytosis and compound fusion in pancreatic beta cells
- 7 November 2012
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 56 (2) , 359-369
Abstract
The molecular basis of the exocytosis of secretory insulin-containing granules (SGs) during biphasic glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells remains unclear. Syntaxin (SYN)-1A and SYN-4 have been shown to mediate insulin exocytosis. The insulin-secretory function of SYN-3, which is particularly abundant in SGs, is unclear.Keywords
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