ALK‐rearranged histiocytosis: Report of two cases with involvement of the central nervous system
- 28 May 2021
- journal article
- research article
- Published by Wiley in Neuropathology and Applied Neurobiology
- Vol. 47 (6) , 878-881
Abstract
Histiocytoses are a heterogeneous group of localized or disseminated diseases, encompassing diverse clonal proliferative disorders of myeloid dendritic and histiocytic cells. Clinical presentation and patient outcome vary greatly, ranging from mild to life-threatening diseases. Rare cases of histiocytosis harbouring ALK rearrangements, mainly with KIF5B as fusion partner, have been recently reported (1-9), with disease involvement of central nervous system (CNS) described only in occasional cases, as a part of a systemic disease or, exceptionally, as the unique manifestation of the disease.Keywords
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