Gain of Function (GOF) Mutant p53 in Cancer—Current Therapeutic Approaches
Open Access
- 31 October 2022
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 23 (21) , 13287
Abstract
Continuous development of personalized treatments is undoubtedly beneficial for oncogenic patients’ comfort and survival rate. Mutant TP53 is associated with a worse prognosis due to the occurrence of metastases, increased chemoresistance, and tumor growth. Currently, numerous compounds capable of p53 reactivation or the destabilization of mutant p53 are being investigated. Several of them, APR-246, COTI-2, SAHA, and PEITC, were approved for clinical trials. This review focuses on these novel therapeutic opportunities, their mechanisms of action, and their significance for potential medical application.Keywords
Funding Information
- Narodowe Centrum Nauki (2019/33/N/NZ4/02773)
- Center for Translational Medicine, Warsaw University of Life Sciences
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