Lycojapodine A, a Novel Alkaloid from Lycopodium japonicum
Authors:
- Xuan-Qin ChenXCXuan-Qin Chen
- Ming-Ming LiMLMing-Ming Li
- Yu ZhaoYZYu Zhao
- Gang XuGXGang Xu
- Xiao ChengXCXiao Cheng
- Li-Yan PengLPLi-Yan Peng
- Min-Jin XieMXMin-Jin Xie
- Yong-Tang ZhengYZYong-Tang Zheng
- Yi-Ping WangYWYi-Ping Wang
- Qin-Shi ZhaoQZQin-Shi Zhao
- 26 February 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 11 (6) , 1397-1400
Abstract
Lycojapodine A, a novel C16N-type Lycopodium alkaloid with an unprecedented 6/6/6/7 tetracyclic ring system, was isolated from the club moss Lycopodium japonicum. The structure and relative stereochemistry were elucidated on the basis of spectroscopic data and were further confirmed by X-ray analysis. A possible biosynthetic pathway for 1 was proposed. Its inhibitory activity on acetylcholinestrease and anti-HIV-1 activity were also evaluated.Keywords
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