cDNA sequence of human β‐preprotachykinin, the common precursor to substance P and neurokinin A
Authors:
- A.J. HarmarA.J. Harmar
- A. ArmstrongAAA. Armstrong
- J.C. PascallJPJ.C. Pascall
- K. ChapmanK. Chapman
- R. RosieRRR. Rosie
- A. CurtisACA. Curtis
- J. GoingJ. Going
- C.R.W. EdwardsCEC.R.W. Edwards
- G. FinkG. Fink
- 10 November 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 208 (1) , 67-72
Abstract
The nucleotide sequence of cDNA encoding the human substance P precursor, β‐preprotachykinin (β‐PPT), has been determined. The source of mRNA was a human laryngeal carcinoid tumour that contained a high concentration of immunoreactive substance P. The human β‐PPT polypeptide is 129 amino acids long and contains regions encoding substance P and neurokinin A, each flanked by basic amino acid residues. Residues 72–107 of the human β‐PPT polypeptide encode the sequence of neuropeptide K, an N‐terminally extended form of neurokinin A recently isolated from porcine brain.Keywords
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