Effect of Substituents in the Syntheses of Phenyl‐Substituted Dibenzonaphthyridines
- 5 August 2013
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 50 (5) , 1049-1063
Abstract
A facile and elegant syntheses of linear and angular phenyl‐substituted dibenzonaphthyridines from 2,4‐dichloroquinolines through anilinoquinolines have been developed. The substituents in the 4th position of the anilinoquinoline and the temperature were found to play a vital role in the regulation of the yield towards the synthesis of the final compounds. The methyl group in the 7th position of the naphthyridin‐11‐ones was found to hinder the N‐methylation reaction sterically, consequently increasing the reaction time than other derivatives.Keywords
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