A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease
Authors:
- Ted WunTWTed Wun
- Denis SoulieresDSDenis Soulieres
- Andrew L FrelingerAFAndrew L Frelinger
- Lakshmanan KrishnamurtiLKLakshmanan Krishnamurti
- Enrico M NovelliENEnrico M Novelli
- Abdullah KutlarAKAbdullah Kutlar
- Kenneth I AtagaKAKenneth I Ataga
- Charles L KnuppCKCharles L Knupp
- Lillian E McMahonLMLillian E McMahon
- John J StrouseJSJohn J Strouse
- Chunmei ZhouCZChunmei Zhou
- Lori E HeathLHLori E Heath
Open Access
- 17 February 2013
- journal article
- research article
- Published by Springer Nature in Journal of Hematology & Oncology
- Vol. 6 (1) , 17
Abstract
Platelet activation has been implicated in the pathogenesis of sickle cell disease (SCD) suggesting antiplatelet agents may be therapeutic. To evaluate the safety of prasugrel, a thienopyridine antiplatelet agent, in adult patients with SCD, we conducted a double-blind, randomized, placebo-controlled study.Keywords
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