Zika Virus Infection Induces Interleukin-1β-Mediated Inflammatory Responses by Macrophages in the Brain of an Adult Mouse Model
Open Access
- 29 June 2023
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 97 (6) , e0055623
Abstract
Zika virus (ZIKV) associated neurological impairments are an important global health problem. Our results suggest that ZIKV infection in the mouse brain can induce IL-1β-mediated inflammation and complement activation, thereby contributing to the development of neurological disorders.Keywords
Funding Information
- National Research Foundation of Korea (2020R1C1C1003379)
- Korea Research Institute of Chemical Technology (KK2333-00)
- National Research Foundation of Korea (RS-2023-00208568)
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