A Comparative Free Radical Scavenging Evaluation of Amantadine and Rasagiline

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Abstract
To evaluated and compare the intrinsic antioxidant ability of amantadine and rasagiline drugs using in-vitro diphenyl-1-picrylhydrazyl assay method. Diphenyl-1-picrylhydrazyl assay method was used to compare the antioxidant activity of rasagiline and amantadine. At lower concentrations (200 - 400 µg/ml), there was a definite difference between amantadine and rasagiline with amantadine showing better antioxidant activity over rasagiline. But at higher doses (600 - 1000 µg/ml) both their antioxidant free radical scavenging activity were comparable. This study proved the intrinsic activity of rasagiline and amantadine which may be beneficial in attenuating the oxidative stress pathways, which were considered responsible for many degenerative diseases.

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