Synthesis and Cytotoxicity of 28-N-Propargylaminoalkylated 2,3-Indolotriterpenic acids
Open Access
- 1 June 2018
- journal article
- research article
- Published by SAGE Publications in Natural Product Communications
- Vol. 13 (6)
Abstract
A new series of propargylaminoalkyl derivatives with N-methylpiperazine and morpholine fragments was obtained by modification of the carboxyl group of [3,2b]-indolotriterpenic acids (N-propargylation, Cu(I) catalyzed Mannich reaction). Cytotoxicity assays demonstrated that oleanane-type conjugate with N-methylpiperazine exhibited high antitumor activity against leukemia cell line SR and non-small cell lung cancer cell line NCI-H460.Keywords
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