Dual delivery of metformin and doxorubicin via the gum acacia–gelatin nanohydrogel disrupts tunnelling nanotube-mediated breast cancer progression

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Abstract
The anticancer mechanism of DOX/MET co-loaded GA–GT nanohydrogel in MCF-7 cells, showing enhanced intracellular drug delivery, PI3K/AKT/mTOR inhibition, suppression of TNT-mediated intercellular communication, and subsequent induction of apoptosis and inhibition of cell migration.
Funding Information
  • Indian Council of Medical Research (2021-10784/CMB-BMS)
  • University Grants Commission (211610122720)

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