Panel of Cephem-Scaffold Probes to Fluorescently Detect Copper through Copper Catalysis

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Abstract
Many fluorescent recognition-based copper probes have been developed, but they generally suffer from a weak fluorescence change upon detection of low-abundance labile copper in biological systems. We have addressed this issue by developing an activity-based copper probe that recycles a portion of copper after detection, thereby amplifying the fluorescence signal. The probe showed good sensitivity and could be applied to in-cell experiments. We expect that similar systems will also be useful for the detection of other bioactive targets that exist at low concentrations.
Funding Information
  • Konica Minolta Imaging Science Foundation (22K06570)
  • Vehicle Racing Commemorative Foundation (6110)
  • Vehicle Racing Commemorative Foundation (6231)
  • Vehicle Racing Commemorative Foundation (6297)
  • Institute of Advanced Energy, Kyoto University (ZE2020C-06)
  • Institute of Advanced Energy, Kyoto University (ZE2021C-03)
  • Japan Society for the Promotion of Science (19K07035)
  • Japan Society for the Promotion of Science (21K15246)

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